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Journal archive > 2008 > N 4 July-August

INFLUENCE OF PROLONGED SOCIAL STRESS ON LIPID METABOLISM IN GOLDEN SYRIAN HAMSTERS

A. L. Zagayko1, L. M. Voronina1, P. A.?Kaliman2, K. V. Strel’chenko1

1National University of Pharmacy, Kharkiv, Ukraine;
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2Karazin Kharkiv National University, Ukraine;
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The changes of total lipids, lipoproteins and their fractions, free fatty acids, triacylglyceroles, free and esterified cholesterol levels and parameters of its metabolism in the blood serum and liver, glucose-6-phosphate dehydrogenase and lysosomal lipase activity in the liver, and also post-heparin lipases activi­ty in blood of hamsters with chronic social stress are investigated. Is has been shown, that in stressed animals the prevalence in early terms of chronic stress lipolysis above lipogenesis is observed. In later terms of chronic stress the lipogenesis activation is also observed which, alongside with active lipolysis, can cause hyperlipidemia in blood. The latter phenomenon is obviously more characteristic of males, while in females the main source of fatty acids in blood is probably lipolysis in the liver. Proathe­rogenic redistribution of lipoprotein fractions, which was observed at chronic stress, becomes complicated by changes of their transformations processes under blood lipases action, in particular, lipases disbalance: by increasing of hepatic lipase activity without lipoprotein lipase activity increase. The increase of CETP activity in HDL, which is observed at stress, can be accompanied by atherogenic LDLВ accumulation in the blood plasma. The chronic social stress is proathe­rogenic owing to lipid and lipoprotein metabolism changes, which lead to the shift of balance during lipids transport and their use by tissues.

Key words: chronic social stress, lipids, cholesterol esterification, lipoprotein, lipolysis, lipogenesis, golden syrian hamsters.

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© The Ukrainian Biochemical Journal