Journal archive > 2008 > N 4 July-August
М. М. Marchenko, G. P. Kopylchuk, О. M. Voloschuk
The work is devoted to investigation of the influence of low doses of preliminary radiation on the fraction content, and oxidizing modification of mitochondrial proteins, unsolvable in 0.05 M sodium-phosphate buffer (11.5), and mtDNA fragmentation. That low-dose irradiation influence mostly manifests itself on the initial stages of tumor growth. It was established that tumor development is accompanied with the changes of mitochondrial proteins fraction content. These changes occured on the intensive oxidizing modification background of the proteins under study and mtDNA fragmentation.
Key words: Guerin’s carcinoma, preliminary fractionating irradiation, low-dose irradiation, mtDNK, mitochondrial proteins, mtDNA oxidizing modification.
The original article in Ukrainian is available for download in PDF format.
© The Ukrainian Biochemical Journal