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Journal archive > 2008 > N 4 July-August

EFFECT OF LOW DOSES OF IONIZING RADIATON ON THE FRACTIONAL CONTENT
OF MITOCHONDRIAL PROTEINS AND mtDNA OF GUERIN’S CARCINOMA

М. М. Marchenko, G. P. Kopylchuk, О. M. Voloschuk

Chernivtsy National University, Ukraine;

The work is devoted to investigation of the influence of low doses of preliminary radiation on the fraction content, and oxidizing modification of mitochondrial proteins, unsolvable in 0.05 M sodium-phosphate buffer (11.5), and mtDNA fragmentation. That low-dose irradiation influence mostly manifests itself on the initial stages of tumor growth. It was established that tumor development is accompanied with the changes of mitochondrial proteins fraction content. These changes occured on the intensive oxidizing modification background of the proteins under study and mtDNA­ fragmentation.

Key words: Guerin’s carcinoma, preliminary fractionating irradiation, low-dose irradiation, mtDNK, mitochondrial proteins, mtDNA oxidi­zing modification.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal