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Journal archive > 2008 > N 4 July-August

NONINVASIVE MONITORING OF THE HEPATOCELLULAR CARCINOMA GROWTH
BY THE METHOD OF 1H AND 23NA MAGNETIC RESONANCE

A. M. Babsky1,2, S. Ju1, S. Topper1, S.?Bennett1, B. Atthe1, G. McLennan1, N.?Bansal1

1Indiana University, Indianapolis, Indiana, USA;
2Ivan Franko National University, Lviv, Ukraine;
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Using diffusion weighted 1H, single-quantum 23Na and triple-quantum-filtered 23Na magnetic resonance imaging water apparent diffusion coefficient (ADC), total tissue Na+ and intracellular Na+ were monitored in hepatocellular carcinoma (HCC) in rats and in the surrounding liver tissue. The tumor water ADC was ~50% higher compared to the nearby healthy liver tissue but did not increase during 28 days of tumor growth (double time 3.9 days). The HCC growth was associated with an increase in both total tissue and intracellular 23Na signal intensity especially after 21 days post-cell inoculation reflecting possible changes in extracellular space and in intracellular ionic metabolism.

Key words: carcinoma, liver, NMR, water diffusion, sodium.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal