title en

THE INFLUENCE OF PROTEIN KINASES ERK, JNK AND NUCLEAR TRANSCRIPTIONAL
FACTOR c-JUN ON CORTICOTROPIN SIGNAL TRANSDUCTION IN ADRENOCORTICAL CELLS

M. D. Tronko, O. I. Kovzun, О. S. Mikosha

Komisarenko Institute of Endocrinology and Metabolism, Academy of Medical Sciences of Ukraine, Kyiv;
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The estradiol effect on the expression level of ERK1/2, JNK, p38 mitogen-activated protein kinases, с-Jun and с-Fos transcription factors in the adrenal cortex of male rats was studied. It was shown that a single corticotropin injection caused significant changes of the ERK1/2 protein kinases levels in the adrenal cortex. This index was 1.6?times higher 1 h after the injection and was decreased 6 h after the injection. The corticotropin influence on JNK level is very significant. The protein kinase JNK level was 2.4-fold increased 1?h after and was decreased 6 h after the injection. However, the level of p38 kinase was not changed in these conditions. The level of c-Jun transcriptional factor increased 1.7 times 1 h after corticotropin treatment and continued decreasing with the increase of time after the injection. The level of c-Fos factor increased 1.7 times only 6 h after the injection. These changes may be an important factor of activation of adrenocortical function provoked by corticotropin.

Key words: corticotropin, protein kinases, transcription factors, adrenocorticocytes.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal