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Journal archive > 2008 > N 3 May-June  

PHOSPHOLIPIDS COMPOSITION OF THE MYOCARDIUM IN PATIENTS WITH ISCHEMIC
HEART DISEASE AND ITS CONNECTION TO ARRHYTHMIAS

I. S. Dykukha2, M. V. Artamanov1, O.?D.?Zhukov1, O. I. Nizhenkivskiy1, V. G. Lizogub2, N. M. Gula1

1Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
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2Bogomolets National Medical University, Kyiv, Ukraine;
3Amosov Institute of Cardiovascular Surgery, Academy of Medical Science of Ukraine, Kyiv;
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The purpose of this study was to establish phospholipid composition of the myocardium in patients with ischemic heart disease, and to estimate possible correlation of biochemical parameters with myocardium extrasystolic activity. The patients (n = 28) including 15 patients with ischemic heart disease and 13 patients with secondary atrium septum defect (control group) were studied. During surgical intervention the right atrium myocardium bioptates were taken. Phospholipid metabolism was studied in the myocardium samples. At the eve of surgical intervention a holter monitoring was performed. Deep changes in the myocardium lipid metabolism were found, including accumulation of free and estherified cholesterol, lysophospholipids, and sphingomyeline. An increase of free cholesterol content was accompanied by accumulation of sphingomyeline. This can be an evidence of changes in the constitution of lipid rafts. Extrasystoles, particularly ventricular ones, in patients with ischemic heart disease might depend on accumulation of lysophospholipids as they took place simultaneously with it.

Key words: ischemic heart disease, heart rhythm disturbances, phospholipids.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal