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Journal archive > 2008 > N 3 May-June  

PECULIARITIES OF TRICARBIXYLIC ACID CYCLE FUNCTIONING IN THE MYOCARDIUM
OF ADULT AND OLD RATS IN THE CASE OF IMMOBILIZATION STRESS

V. N. Shvets1, V. V. Davydov2

1Zaporozhie State Medical University, Ukraine;
2Institute of Children and Adolescents Health Care, Academy of Medical Scinces of Ukraine, Kharkov;

Indices showing Krebs cycle functioning in the hearts of adult and old rats subjected to 30 minu­tes immobilization were studied in order to find out the causes of age-related increase of heart sensitivity to stress. The studies have shown that compensatory changes of energy metabolism promoting­ limitation of stress-induced decrease of energy supply of the heart muscle took place in the myocardium mitochondria in adult and old rats during immobilization stress. The changes are associated with maintenance of high rate of red-ox reactions in the Krebs cycle and increase of myocardium respiration in old rats, and with an increase of the  FAD-dependent processes in tissue respiration in adult rats.

Key words: ageing, myocardium, immobilization stress, Krebs cycle.

The original article in Russian is available for download in PDF format.

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