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Journal archive > 2008 > N 2 March-April

INFLUENCE OF CATTLE CORD BLOOD FRACTION BELOW 5 kD ON BIOCHEMICAL
PARAMETERS OF BLOOD AT EXPERIMENTAL CHRONIC STOMACH ULCER IN RATS

A. K. Gulevsky, Ye. S. Abakumova, N. N. Moiseyeva, O. L. Dolgikh

Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov;
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Influence of cattle cord blood fraction (below 5 kD) on lipid peroxidation product content and alkaline phosphatase activity in peripheral blood was studied on the experimental subchronic stomach­ ulcer model in rats. It has been shown that the fraction administrations normalize thiobarbituric-active product content and alkaline phosphatase activity in blood, which testifies to decreasing inflammatory reaction in the mucous membrane of the stomach. The fraction administrations accelera­te the processes of regeneration of the mucous membrane of the stomach up to complete healing of ulcer defects. Cord blood fraction below 5?kD from cattle possesses antiulcer activity which is analogous to the actovegin activity. It has been shown by gel-penetrating chromatography that the pattern of cord blood fraction low molecular substances is different from the actovegin pattern both qualitatively and quantitatively.

Key words: cord blood, low molecular fraction below 5 kD, actovegin, subchronic stomach­ ulcer, reparation, alkaline phosphatase, TBA-active products.

The original article in Russian is available for download in PDF format.

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