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Journal archive > 2008 > N 2 March-April

DISORDERS IN LIPID COMPOSITION AND PROPERTIES OF PLASMA MEMBRANE
OF PLACENTAL EPITHELIAL CELLS OF VILLOUS CHORION UNDER
THE INFLUENCE OF CHLAMYDIAL INFECTION

S. V. Yablonska1, T. V. Fartushok2, S. P. Veselsky1, O. A. Kondratyuk1, V. N. Besedin2, V. K. Rybalchenko1

1Taras Shevchenko Kyiv National University, Ukraine;
2Danylo Halytsky Lviv National Medical University, Ukraine;
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Lipid composition of plasma membranes of placental epithelial cells of villous chorion of healthy women and those with chlamydiosis has been studied. Lipid composition of plasma membranes of ill women differs from that of healthy women by reduction of total phospholipids quantity, by the increase of the level of free cholesterol and free fatty acids. A disturbance in the ratio between certain lipid fractions and increasing quantity of lysophospholipids is observed. Two-fold oppression of plasma membranes Na+,K+-ATPase activity of placental epithelial cells of villous chorion in ill women has been detected but Mg2+,Ca2+-ATPase activity has not changed. Thus chlamydial infection causes significant disorders in lipid composition and functioning of epithelial cells membranes of chorion.

Key words: plasma membrane, phospholipids, Na+,K+-ATPase, Mg2+,Ca2+-ATPase, chlamydial infection.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal