Journal archive > 2008 > N 1 January-February   

MATHEMATICAL SIMULATION OF TRANSMEMBRANE CALCIUM TRANSPORT
KINETICS IN SMOOTH MUSCLE CELLS

P. F. Zhuk, S. O. Karakhim, V. F. Gorchev, S. O. Kosterin

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
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A mathematical model, which describes kinetics of transmembrane calcium transport in a smooth muscular cell, has been elaborated and investigated taking into account that the change of calcium cations concentration within a cell is determined by two mutually opposite processes: an increase of a carrying capacity of calcium channels of plasma membrane under signal substance action and calcium removal from the intracellular space by Mg2+,ATP-dependent calcium pump localized on the plasma membrane. The fundamental difference of the proposed model against the models analyzed in literature before is that the cellular system returns to the initial stationary state after enzyme-catalysed transformation of the signal substance. The results of calculations showed that this model really described the experimental kinetics of the transmembrane calcium transport. In this paper the influence of different parameters (Michaelis constant and ultimate rate of calcium pump, initial concentrations of signal substance and enzyme decomposing it, rate constants) on kinetics of calcium transport through the plasma membrane has been investigated in detail.

Key words: mathematical model, smooth muscular cell, plasma membrane, transmembrane calcium transport, calcium channel, receptor, intracellular calcium, calcium pump, Michaelis constant, mediator.

The original article in Russian is available for download in PDF format.

 

 

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