Journal archive > 2008 > N 1 January-February   

AGE-RELATED PECULIARITIES OF?GLUTATHIONE CONTENT CHANGES
IN THE BRAIN OF RATS DURING IMMOBILIZATION STRESS

V. V. Rudenko, A. V. Goloborodko, A. V. Redko, V. V. Davydov

SI Institute of Children and Adolescents Health Care, Academy of Medical Sciences of Ukraine, Kharkov;

The work is aimed at studying age-related peculiarities as regards glutathione content changes in the brain of rats under immobilization stress. It has been established that some changes in the content of reduced glutathione take place in the brain in the process of ontogenesis. During immobilization stress the content of this metabolite decreases in the brain of all age groups of rats under study. To a greater extent this shift manifests itself in 2- and 24-month-old rats which are characterized by more active stress-stimulated free-radical proces-ses in the brain and by an initially higher level of reduced glutathione.

Key words: rats, immobilization stress, brain, ontogenesis, glutathione.

The original article in Russian is available for download in PDF format.

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