Journal archive > 2008 > N 1 January-February

STATE OF ANTIOXIDANT PROTECTION АND SYSTEM L-ARGININ–NITROGEN OXYDE
IN BLOOD AT PATIENTS WITH UROGENITAL CHLAMYDIOSIS

G. K. Kondakova, O. V. Ermoshenko, K. O. Kalekina, V. N. Tsymbal

State Institution: Institute of Dermatology and Venerology, Academy of Medical Sciences of Ukraine, Kharkiv;

The system L-arginine-nitrogen oxide plays a significant role in maintenance of the anti-infectious protection of an organism. A condition of the given system and activity of a enzymatic part of antiradical protection in the blood of patients with chlamydiosis has been studied. Obtained data specify an intensification of processes of an oxidizing way of recycling of arginine in an organism of patients. Substantial increase of NO-synthase activity and insignificant activity of arginase in the blood is revealed. The level of nitrite-anion in blood cells of patients authentically increases: 1.7 times in erythrocytes, and 1.4 times in lymphocytes. It is shown, that in patients with chlamydiosis glutathione system is intensified, that is evidenced by an increase glutathione-peroxidase activity and authentic increase of glutathione level. It is assummed that the established features of nit­rogen oxide exchange play a significant role in formation of a pathological condition at urogenital chlamydia infections.

Key words: nitrogen oxide, arginase, NO-synthase, antiradical protection, urogenital chlamуdiosis.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal