Journal archive > 2008 > N 1 January-February

ROLE OF NON-HAEM IRON IN PROTECTING EFFECT OF ECDYSTERONE ON DEVELOPMENT
OF STREPTOZOTOCINE-INDUCED HYPERGLYCAEMIA IN RATS

Ju. P. Korkach1, N. O. Dudchenko2, A. V. Kotsuruba1, O. D. Prysyazhna3, V. F. Sagach3

1Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
2Institute for Applied Problems in Physics and Biophysics, National Academy of Sciences of Ukraine, Kyiv;
3Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv;
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Chronic hyperglycaemia (60 days) which developed after streptozotocine (STZ) administration (5 mg/100 g) in rats was accompanied with develop­ment of severe endothelial dysfunction as well as with disturbed non-haem iron metabolism. It was established by EPR spectroscopy method that STZ administration reduced transferrin levels in the blood as well as pools of iron associated with blood transferrin and with ferritin in the heart and aorta of rats with hyperglycaemia. Chronic ecdysterone administration (100 ng/100 g, 60 days) protects hyperglycaemia development by preventing of non-haem iron metabolism disturbance. These data suppose participation of non-haem iron in mechanisms of ecdysterone protection of streptozotocine-induced hyperglycaemia and ischemia.

Key words: non-haem iron, EPR, ecdysterone, hyperglycaemia, streptozotocine, heart, aorta, blood.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal