Journal archive > 2008 > N 1 January-February

PECULIARITIES OF LEUCOTRIENES METABOLISM IN THE RAT ORGANISM UNDER E-HYPOVITAMINOSIS

S. B. Silonov, G. V. Donchenko, R. P. Morozova

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
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Some changes take place in the spectrum of fatty acid, cholesterol and individual phospholi­pids’ composition in the rat liver, under E-hypovitaminosis, that can play a considerable role in the cell damage. The level of cysteinyl leucotriene decreases in the blood and liver under E-hypovitaminosis and it rises to the control level under vitamin?Е correction. This demonstrates the influence of tocopherol on 5-LO pathway arachidonic acid.

Key words: arachidonic acid, tocopherol, E-deficiency diet, phospholipids, leucotrien.

The original article in Ukrainian is available for download in PDF format.

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