Journal archive > 2008 > N 1 January-February
V. V. Vlizlo, V. V. Stadnyk, Ch. Ya. Mayor, M. V. Kinakh, P. I. Verbitskii, М. M. Kozak
It is established that except for already known influence of pentosan polysulphate (SP-54) on the expression of pathological prion, this preparation has an inhibiting effect in respect of physiological prion. Moreover, the reduction of concentration of physiologycal prion is registered in the central and peripheral organs of the prion-replicating system. It was also shown that inhibition of the studied protein leads to the growth in copper and zinc concentration in the proper organs and tissues, but at the same time activity of Cu/Zn-dependent superoxide dismutase does not change.
Key words: physiological prion, pentosan polysulphate, Cu/Zn-dependent superoxide dismutase.
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