Journal archive > 2008 > N 1 January-February

LEVEL OF PHYSIOLOGICAL FORM OF PRION IN THE RAT TISSUE
AS AFFECTED BY PENTOSAN POLYSULPHATE (SP-54)

V. V. Vlizlo, V. V. Stadnyk, Ch. Ya. Mayor, M. V. Kinakh, P. I. Verbitskii, М. M. Kozak

Institute of Animal Biology, Ukrainian Academy of Agricultural Sciences, Lviv;
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 It is established that except for already known influence of pentosan polysulphate (SP-54) on the expression of pathological prion, this preparation has an inhibiting effect in respect of physiological prion. Moreover, the reduction of concentration of physiologycal prion is registered in the central and peripheral organs of the prion-replicating system. It was also shown that inhibition of the studied protein leads to the growth in copper and zinc concentration  in the proper organs and tissues, but at the same time activity of Cu/Zn-dependent superoxide dismutase does not change.

Key words: physiological prion, pentosan polysulphate, Cu/Zn-dependent superoxide dismutase.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal