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Journal archive > 2007 > N 6 November-December

MODIFYING EFFECT OF LOW-MOLECULAR METABOLITIES ON THE STATE
OF EXTRACELLULAR MATRIX OF CONNECTIVE TISSUE OF ANIMALS
 
Т. Т. Volodina1, Т. М. Pechenova1, N. D. Dzvonkevich1, N. М. Popova1, N. V. Silonova1,
V. S. Astahova2, L. М. Panchenko2, M. F. Guly1, V. О. Mikhaylovsky1
 
 
1Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
2Institute of Travmatology and Orthopedy, АМS of Ukraine, Kyiv;
е-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

On the basis of complex approach to bone and haematopoetic tissue interaction the authors studied the influence of low weight metabolites on stromal fibroblasts and components of extacellular matrix of bone and skin (collagen and glycosaminoglycans). Specificity of different metabolites action on physico-chemical abilities of type I collagen, amino acid composition changes, surface charge, ratio of ?- and ?-compounds, BrCN-fragments of ?-1 component cross-links was shown. The dose dependence of formіate effect on processes of proteins glycosilation, cross-linking in bone and cartilage connective tissue and serum glycoproteins was established. The results obtained showed sensitivity of the bone tissue exstacellular matrix to influence of low-weight metabolites action at the level of post-synthetic modification of its components, their intermolecular interaction and process of osteogenesis.

Key words: leukemia, fibroblasts, amino acids, formiat, collagen, glycosaminglycans.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal