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Journal archive > 2007 > N 6 November-December

AGE PECULIARITIES IN CHANGES OF FREE RADICAL OXIDATION PROCESSES
IN THE BRAIN OF RATS WITH HYPOTHYROIDISM

Khaddad Aikham Ali1, V. V. Davydov2

1Kharkov Medical Academy of Postgraduate Education, Ukraine;
2Institute of Children and Adolescent Health Care, Academy of Medical Sciences of Ukraine, Kharkov;

The objective of the present experiment was to study age peculiarities of free radical protein oxidation and lipid peroxidation in brain of 1.5 month-old and 12-month-old rats with drug-induced hypothyroidism. It has been shown that hypothyroidism in both 1.5-month and 12-month old rat is accompanied by the oxidative stress in the brain. It manifests by an increase of content of lipid peroxidation products and protein carbonyls in mitochondrial and microsomal fractions. Hypothyroidism decreases the prooxidant effect of exercises on the brain mitochondria.

Key words: brain, hypothyroidism, exercises, oxidative stress, lipid peroxidation, free radical protein oxidation.

The original article in Russian is available for download in PDF format.

© The Ukrainian Biochemical Journal