title en

Journal archive > 2007 > N 5 September-October  

NONCOENZYME FUNCTION OF VITAMIN PP AND ITS BIOLOGICALLY
ACTIVE DERIVATIVES: THE CURRENT STATE OF THE PROBLEM

I. O. Shymansky, T. M. Kuchmerovska

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;

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This review is devoted to the current state of investigations of vitamin PP and nicotinamide dinucleotides noncoenzyme functions. Particular attention has been focused on the role of these compounds in post-translation modification of proteins (mono- and poly-ADP-ribosylation), in regulation of gene activity, calcium homeostasis and Са2+ signalling as well as in modulation of synaptic transmission. Biological significance of these processes in cell function was elicited. The role of deregulation of vitamin PP mediated signalling mechanisms involved in control over the cell function under conditions of different diseases was emphasized.

Key words: vitamin РР, nicotinamide dinucleotides, ADP-ribosylation of proteins, Са2+ signalling, neuromodulation.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal