title en

Journal archive > 2007 > N 5 September-October  

ROLE OF INTERACTION OF?METABOLISM PATHS OF?FORMALDEHYDE
AND NITRIC OXIDE IN THE MECHANISM OF THEIR TOXIC EFFECT.
3. MAIN METABOLISM SITES OF FORMALDEHYDE AND NITRIC OXIDE
MEDIATING THEIR EFFECT

N. P. Dmitrenko1, A. Holian2

1Medvedev Institute of Ecohygiene and Toxicology, Kyiv, Ukraine;
2Center of Environmental Health Sciences, The University of Montana, USA;
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.; This email address is being protected from spambots. You need JavaScript enabled to view it.

Data are presented concerning the basic metabolism sites, the reaction paths crossing in them and regulatory and toxical effect of formaldehyde and nitric oxide being mediated through them. In particular, they include: glutathione-formaldehyde-dependent dehydrogenase path of S-nitrosoglutathione reduction, semi-carbaside-sensitive amino-oxidase (SSAO) and NO-synthase systems; transformation of thioproline and metallothioneines, including nitrosation reactions. Possibilities of hexamethylenetetramine synthesis in the organism as well as its metabolism in conditions of formaldehyde hyperproduction and nitrosative stress are discussed. The role of metabolism sites, common for formaldehyde and nitric oxi­de, in the mechanisms of toxical effect of these compounds and development of pathologic states is considered.

Key words: nitric oxide, formaldehyde, glutathione-dependent formaldehyde dehydrogenase, S-nitrosoglutathione reductase, semicarbaside-sensitive aminoxidase, thioproline, hexamethy­lene tetramine, metallothioneines.

The original article in Russian is available for download in PDF format.

© The Ukrainian Biochemical Journal