ROLE OF INTERACTION OF METABOLISM PATHS OF FORMALDEHYDE AND NITRIC OXIDE IN THE MECHANISM OF THEIR TOXIC EFFECT. 3. MAIN METABOLISM SITES OF FORMALDEHYDE AND NITRIC OXIDE MEDIATING THEIR EFFECT (N.P. Dmitrenko, A. Holian)

title en

Journal archive > 2007 > N 5 September-October

ROLE OF INTERACTION OF?METABOLISM PATHS OF?FORMALDEHYDE

AND NITRIC OXIDE IN THE MECHANISM OF THEIR TOXIC EFFECT.

3. MAIN METABOLISM SITES OF FORMALDEHYDE AND NITRIC OXIDE

MEDIATING THEIR EFFECT

N. P. Dmitrenko¹, A. Holian²

¹Medvedev Institute of Ecohygiene and Toxicology, Kyiv, Ukraine;

²Center of Environmental Health Sciences, The University of Montana, USA;

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Data are presented concerning the basic metabolism sites, the reaction paths crossing in them and regulatory and toxical effect of formaldehyde and nitric oxide being mediated through them. In particular, they include: glutathione-formaldehyde-dependent dehydrogenase path of S-nitrosoglutathione reduction, semi-carbaside-sensitive amino-oxidase (SSAO) and NO-synthase systems; transformation of thioproline and metallothioneines, including nitrosation reactions. Possibilities of hexamethylenetetramine synthesis in the organism as well as its metabolism in conditions of formaldehyde hyperproduction and nitrosative stress are discussed. The role of metabolism sites, common for formaldehyde and nitric oxide, in the mechanisms of toxical effect of these compounds and development of pathologic states is considered.

Key words: nitric oxide, formaldehyde, glutathione-dependent formaldehyde dehydrogenase, S-nitrosoglutathione reductase, semicarbaside-sensitive aminoxidase, thioproline, hexamethylene tetramine, metallothioneines.

The original article in Russian is available for download in PDF format.