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Journal archive > 2007 > N 5 September-October  

INFLUENCE OF HOMOCYSTEINE, CYSTEINE, AND THEIR DERIVATIVES
ON PLATELET LINK OF HEMOSTASIS SYSTEM

N. V. Zaichko1,2, O. O. Pentiuk2, V. L. Karbovskyy3

1Ukrainian State Scientific Research Institute of Invalid Rehabilitation, Vinnytsia;
2Pirohov Vinnytsia National Medical University;
3Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
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The influence of homocysteine, homocysteine thiolactone, cysteine and their derivatives on activation and aggregation of human platelets was investigated using the model systems in vitro. It was established that homocysteine and cysteine increased platelet aggregation induced by ADP, epinephrine, or collagen. Their action began in a range of concentrations such as their physiological blood levels (10 µМ) and was increasing with the rise of their concentrations. Cysteine increased ADP-induced platelet aggregation, hardly any affect on epinephrine-induced platelet aggregation and depressed collagen-induced platelet aggregation in the highest concentration (1000 µМ). Their disulfides and thioethers did not influence platelet aggregation.

Key words: platelet, aggregation, homocysteine, cysteine, homocysteine thiolactone.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal