N. V. Zaichko1,2, O. O. Pentiuk2, V. L. Karbovskyy3
The influence of homocysteine, homocysteine thiolactone, cysteine and their derivatives on activation and aggregation of human platelets was investigated using the model systems in vitro. It was established that homocysteine and cysteine increased platelet aggregation induced by ADP, epinephrine, or collagen. Their action began in a range of concentrations such as their physiological blood levels (10 µМ) and was increasing with the rise of their concentrations. Cysteine increased ADP-induced platelet aggregation, hardly any affect on epinephrine-induced platelet aggregation and depressed collagen-induced platelet aggregation in the highest concentration (1000 µМ). Their disulfides and thioethers did not influence platelet aggregation.
Key words: platelet, aggregation, homocysteine, cysteine, homocysteine thiolactone.
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© The Ukrainian Biochemical Journal