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Journal archive > 2007 > N 4 July-August 

SOME MECHANISMS OF LYMPHOID CELL DIFFERENTIATION

V. A. Halytskiy, S. V. Komisarenko

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
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Lymphoid cells differentiation is a well coordinated and highly integrated process, which is defined by the interaction of genes and cell signa­ling pathways of the maturing cell with the microenvironment factors. In the course of such interaction in the maturing cell, new ways of signal transduction appear, and on the basis of such new ways new gene networks are formed, which start to play rapidly, even during the course of the present or  following cell specialization stage, the key role in the further cell fate.

Key words: differentiation, lymphoid cell, gene network, gene module, transcription factor, cytokine.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal