INFLUENCE OF ENDOGENOUS LECTINS ON HCO3–-ATPase ACTIVITY OF?THE?BRAIN GLIA
N. I. Koshoridze, K. O. Menabde, N.?B.?Surguladze, T. M. Vardiashvili, R.?O.?Solomonia, N. G. Aleksidze
The influence of galactose- (GL-GAL) and inositol-specific (GL-I) lectins from the glial cells of the chicken brain fraction on the HCO3–-ATPase activity was studied. It was established that enzyme activity changes depended on the concentration of lectins. It must be said that the presence of these lectins also changes the pH optimum of enzyme activity. Calcium ions have an inhibitory effect on the HCO3–-ATPase activity. This effect sharply decreases as a result of the presence of GL GAL and GL-I. The modulator influence of lectin on the HCO3–-ATPase activity is determined by changing the enzyme affinity for Cа2+ ions.
Key words: brain, glia, lectin, HCO3–-ATPase.
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