NADP POOL STATE AND ACTIVITY OF NADP-DEPENDENT DEHYDROGENASES IN THE HEART TISSUE OF ADULT AND OLD RATS UNDER IMMOBILIZED STRESS (V.N. Shvets, V.V. Davydov)

title en

Journal archive > 2007 > N 2 March-April

NADP POOL STATE AND ACTIVITY OF NADP-DEPENDENT DEHYDROGENASES

IN THE HEART TISSUE OF ADULT AND OLD RATS UNDER IMMOBILIZED STRESS

V. N. Shvets¹, V. V. Davydov²

¹Zaporozhie State Medical University, Ukraine;

²Institute of Children and Adolescents Health Care, Academy of Medical Sciences of Ukraine, Kharkov;

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To reveal the reasons of age-specific change of heart sensitivity to stress, the content of oxidized and reduced NADP and activity of NADP-dependent dehydrogenase in myocardium of adult and old immobilized rats have been studied. It has been established that in the process of aging the amount of reduced NADP decreases in the old rat heart. At the same time the activity of NADP-dependent dehydrogenase decreases in postmitochondrial fraction of old rat myocardium as compared to adult rats. There is no change in the amount of reduced NADP in the heart of both rat age groups after 30-minute immobilization. The activity of NADP-dependent dehydrogenase in postmitochondrial fraction of myocardium in adult rats remains on the initial level while activation of NADP-dependent malate dehydrogenase and glucose 6-phosphate dehydrogenase appears in old rats.

Key words: ageing, myocardium, immobilized stress, NADP, NADP-dependent dehydrogenase.

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