I. A. Shepelova, E. A. Derkach, N. M. Melnikova
The influence of cadmium sulfate on concentration of glucose, lactate, piruvate, ?-ketoglutarate, malate, oxaloacetate in blood of 3-, 6- and 18-month-old poisoned rats was established the results of our researches. It was found, that poisoning of rats by cadmium sulfate causes the rise of concentration of glucose, metabolites of citric acid cycle and glycolysis in blood of animals of all age groups explored. The research results prove that in blood of 3-month-old poisoned rats the level of glycolysis and citric acid cycle activation is considerably higher in comparison with that of 6- and 18-month-old animals. As a result, a comparison of age-specific dynamics of changes of carbohydrate metabolism indices in the blood of rats, poisoned by cadmium showed that the organism of 3 month-old rats is more sensitive to toxic influence of cadmium.
Key words: cadmium sulfate, glucose, lactate, piruvate, ?-ketoglutarate, malate, oxaloacetate, glycolysis, citric acid cycle, blood, rats, age, poisoning.
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