R. P. Morozova1, E. P. Pasichna1, G.?V.?Donchenko1, T. F. Kastrikina2, S. B.?Silonov1, O. M. Palivoda1, N.?V.?Delemenchuk1
The character of some lipids level change?– cholesterol and phospholipids – as basic lipid components of cell membranes in the guinea-pig brain and liver tissue, and in serum in conditions of development of experimental autoimmune encephalomyelitis (EAE) have been investigated on the 11th, 21st, 27th day after inoculation. It has been detected, that the level of the investigated lipids changes wavely and indifferent-direction in the brain tissue on the 21st day of EAE. Similar variability observed in the activity of proteolytic ferment calpain, which is authentically reduced in the brain tissue by the 11th hour and increases up to the test objective level in the subsequent periods of EAE development. In the liver the level of ?-tocopherol is reduced, while the content of studied lipids does not change. The investigated parameters can be attributed to the factors, which play an essential role in structural stability of cell membranes and their variability in conditions of EAE development is related to the processes of nervous cells demyelinisation and, hence to occurrence of such pathology as multiple sclerosis in people.
Key words: cholesterol, phospholipids, myelin, calpain, ?-tocopherol, experimental autoimmune encephalomyelitis, multiple sclerosis.
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