title en

Journal archive > 2006 > N 4 July-August

THE ROLE OF PROTEIN KINASE C IN INTRACELLULAR REGULATION MECHANISMS
OF ADRENOCORTICAL FUNCTION IN NORMY AND WITH PATHOLOGY

O. I. Kovzun, V. M. Pushkarev

Komissarenko Institute of Endocrinology and Metabolism, Academy of Medical Sciences of Ukraine, Kyiv;
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The data on the role of protein kinase C enzymes family in regulation of biochemical processes in adrenocortical cells and other types of steroid-producing cells were analyzed. The involvement of these protein kinase reactions in signal transduction of main regulators of adrenocortical function – ACTH, angiotensin II and potassium ions was considered. Data about interactions and transregulation influences between different secondary messenger systems, which mediate intracellular signal transduction of agonists and provide functional activity of adrenocortical cells are discussed. The participation of protein kinase C is shown in changing of the steroidogenic genes expression. The role of protein kinase C isoforms in tumorogenesis is described.

Key words: protein kinase C, steroidogenesis, ACTH, angiotensin II, potassium ions, adrenal tumors.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal