CORRECTION OF DISTURBANCES OF DNA METHYLATION AS A POSSIBLE WAY TO MODULATION OF MALIGNANT CELLS DRUG RESISTANCE (V.F. Chekhun, D.O. Mykytenko, N.Yu. Lukyanova, I.P. Pogribny)

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Journal archive > 2006 > N 6 November-December

CORRECTION OF DISTURBANCES OF DNA METHYLATION AS A POSSIBLE WAY

TO MODULATION OF MALIGNANT CELLS DRUG RESISTANCE

V. F. Chekhun¹, D. O. Mykytenko¹, N. Yu. Lukyanova¹, I. P. Pogribny²

¹Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS of Ukaraine, Kyiv, Ukraine;

²National Center for Toxicological Research, Jefferson, Arkansas USA;

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The role of DNA methylation in functioning of a normal and cancer cell is shown in this review. The value of methylation in functioning of the systems which are involved in the process of formation of malignant cells drug resistance phenotype (regulator proteins of cellular cycle, DNA-adducts reparation, transport systems, systems of detoxication and adhesion) is explicated. The prospects of the antineoplastic therapy directed to regulation of DNA methylation by means of homocysteine and demethylation agents are analyzed.

Key words: drug resistance, tumor, DNA methylation, correction of methylation alterations, homocysteine.

The original article in Ukrainian is available for download in PDF format.