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Journal archive > 2006 > N 6 November-December

INTERACTION OF CHAOTROPICALLY MODIFIED IMMUNOGLOBULINS
WITH PROTEIN AND GLICOLIPID ANTIGENS

A. I. Gоrdienko, N. V. Khimich

Crimean State Medical University, Simferopol, Ukraine;
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The features of interaction of native and chao­tropically modified immunoglobulins with proteins (оvalbumin) and glicolipids (lipopolysaccharides, LPS) enterobacteria Escherichia coli K235, Salmonella minnesota and Salmonella enteritidis have been investigated. It has been established, that after processing of native antibodies with 3.5?М KSCN their ability to contact to the specified antigenes repeatedly grows. Besides the intensity of interaction of modified immunoglobulins with the mentioned above antigenes was various, that is determined by the presence of structural distinctions between antigen determinants of proteins and glycolipid antigens, and also between O-polysaccharide chains of LPS in different species of enterobacteria.

Key words: polyreactive immunoglobulins, lipopolysaccharides, оvalalbumin.

The original article in Russian is available for download in PDF format.

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