title en

Journal archive > 2006 > N 6 November-December

FEATURES OF INTERACTION OF?MODULATORS OF ADENYLATE CYCLASE
AND PHOSPHOINOSITIDE SIGNALING SYSTEMS OF THE CELL
WITH LIPID LANGMUIR MONOLAYERS

A. M. Lyakhov, V. V. Prokopenko, R.?A.?Prokopenko. S. Ye. Mogilevich

Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Kyiv;
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Interaction of two groups of bioregulators, which oppositely affect activity of adenylate cyclase and phosphoinositide cellular signaling systems, with the Langmuir monolayer films made of natural lecithin was studied. Most significant influence on the structural and energy characteristics of lipid monolayers was revealed for the group of bioregulators, which inhibit polyphosphoinositide signaling system or/and activate adenylate cyclase signaling system. It is shown, that using the cluster analysis the bioregulators can be divided into two groups according to general orientation of their action on the considered systems of transduction of a signal.

Key words: bioregulators, adenylate cyclase signaling system, phosphoinositide signaling system, Langmuir monolayer films, natural lecithin, physiologically active compounds.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal