EFFECT OF 17?-ESTRADIOL ON CONTENT OF CYCLIC NUCLEOTIDES AND PROTEIN KINASES A AND C ACTIVITY IN HUMAN ADRENAL CORTEX 9E.M. Grinchenko, O.I. Kovzun, O.S. Mikosha)

title en

Journal archive > 2006 > N 5 September-October

EFFECT OF 17?-ESTRADIOL ON CONTENT OF CYCLIC NUCLEOTIDES AND PROTEIN

KINASES A AND C ACTIVITY IN HUMAN ADRENAL CORTEX

E. M. Grinchenko, O. I. Kovzun, O. S. Mikosha

Komissarenko Institute of Endocrinology & Metabolism, Academy of Medical Sciences of Ukraine, Kyiv;

e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

The influence of 17?-estradiol on cAMP and cGMP levels, protein kinases A and C activity and corticosteroids secretion was investigated in postoperative human adrenal cortex tissue. cAMP accumulation in adrenocorticocytes increased under the influence of 17?-estradiol. In vitro estradiol raised the activities of protein kinases A and C in membrane fraction of adrenal cortex tissue. Significant increasing of steroidogenesis was observed. These data support our conclusion that cAMP dependent signaling system is involved in activation of steroidogenesis by 17?-estradiol.

Key words: estradiol, сАМР, сGMP, protein kinase А, protein kinase С, adrenal cortex.

The original article in Russian is available for download in PDF format.