Journal archive > 2006 > N 5 September-October
E. M. Grinchenko, O. I. Kovzun, O. S. Mikosha
The influence of 17?-estradiol on cAMP and cGMP levels, protein kinases A and C activity and corticosteroids secretion was investigated in postoperative human adrenal cortex tissue. cAMP accumulation in adrenocorticocytes increased under the influence of 17?-estradiol. In vitro estradiol raised the activities of protein kinases A and C in membrane fraction of adrenal cortex tissue. Significant increasing of steroidogenesis was observed. These data support our conclusion that cAMP dependent signaling system is involved in activation of steroidogenesis by 17?-estradiol.
Key words: estradiol, сАМР, сGMP, protein kinase А, protein kinase С, adrenal cortex.
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