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Journal archive > 2006 > N 5 September-October

EFFECT OF AMINOGUANIDINE ON OXIDATIVE MODIFICATION OF PROTEINS
UNDER EXPERIMENTAL DIABETES MELLITUS IN RATS

I. V. Brodуak, N. O. Sybirna

Ivan Franko Lviv National University, Ukraine;
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It was shown that administration of aminoguanidine is accompanied by a decrease of the content of nitric oxide stable metabolites, as well as protein carbonyl groups in leukocytes and blood plasma in diabetic and control animals. Aminoguanidine is proposed to be used for pharmacological correction of NO biosynthesis. Aminoguanidine, being the selective iNOS inhibitor, antioxidant and the factor eliminating posttranslational protein nitrozylation and oxidative modification, weaken the toxic effects of NO and positively modulates the pathological state caused by NO hyperproduction.

Key words: aminoguanidine, oxidative modification of proteins, nitrite, nitrate, leukocytes, experimental diabetes mellitus.

The original article in Ukrainian is available for download in PDF format.

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