Mohamad Salem Jzaerli, V. V. Davydov
The objective of the present experiment was to study free radical protein oxidation and lipid peroxidation in the liver of 1.5-month-old and 12 month-old rats with drug-induced hypothyroidism caused by exercises. The results of the present study suggest that intensive exercises are accompanied by an increase of intensity of free radical processes in the liver. Hypothyroidism and exercises do not greatly affect free radical processes in the liver of 12-month-old rats but result in additional stimulation of free radical oxidation in subcellular liver fractions of 1.5-month-old rats. An increase of free radical processes in the liver of 1.5-month-old rats with hypothyroidism caused by exercises is associated neither with changes in the first level antioxidant defense system enzymes function, nor with modulation of hepatocytes subcellular sensitivity to prooxidants. Such change is due largely to an increase of free radical production in the liver cells.
Key words: liver, hypothyroidism, oxidative stress, lipid peroxidation, free radical protein oxidation, exercises.
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