Journal archive > 2006 > N 3, May-June

TECHNOLOGY OF IMMUNOGLOBULIN PRODUCTION. I. TECHNOLOGICAL ASPECTS OF PURIFICATION

 

G. L. Volkov

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
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Plasma-derived intravenous immunoglobulin (IVIG) preparations have become the major plasma products on the world blood product market due to the successful application for the prophylactic prevention of infectious diseases and replacement therapy in autoimmune and inflammatory diseases­. In this review classical manufacturing processes as well as new chromatographic, membrane, and mixed industrial technologies are discussed with respect to the cost and amount of the final product of high quality and virus- and prion-safety which is to be obtained.

Key words: donor blood plasma, immunoglobulins, fractionation, alcohol peleting, chromotographic methods, membrane filtration, target product, yield, purification grade, virus inactivation.

Recieved: 2006-05-16
Published at the site: 2006-09-19

The original article in Russian is available for download in PDF format.

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