Journal archive > 2006 > N 3, May-June

PROTHROMBINE AND E-FRAGMENT COMPLEXATION PROCESS

O. M. Savchuk, E. M. Krasnobryzha, V. F. Gorchev, Т. М. Chernyshenko, S. P. Gavrylyuk, Т. М. Platonova

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
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The study is devoted to research of the blood coagulation key proenzyme complexation process. It is prothrombin, and the E-fragment of fibrin can be a component in blood circulation.
It is shown, that non-enzyme activation of prothrombin by the E-fragment proceeds as a result of formation of stable non-covalent prothrombin-E fragment complex. The cringle structures of prothrombin and the N-terminal site of ?-chain of Е-fragment of fibrin are important for formation of the given complex. It has been defined, that other fragments of fibrin (D and DD) are not capable to induce amydolytic activity of prothrombin.

Key words: prothrombin, Е-fragment of fibrin, prothrombin–E-fragment of fibrin complex.

Recieved: 2006-05-16
Published at the site: 2006-09-20

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal