STREPTOKINASE INFLUENCE ON THE CONTENT OF PLASMINOGEN
ACTIVATOR INHIBITOR OF TYPE 1
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
The influence of streptokinase on plasminogen activators inhibitor of type I (PAI-1) was investigated with the use of model systems in vitro and in vivo.
It was defined, that intravenous streptokinase injection causes an increase in PAI-1 content in mammals’ blood plasma. Experiments in vitro have shown that the increase in PAI-1 concentration takes place as a result of streptokinase action. It occurs due to platelets activation with subsequent PAI-1 secretion from their ?-granules. It is established, that PAI-1 is secreted by platelets both in free and in complex forms.
The data obtained in the work, allow to assume, that the simultaneous substantial increase in PAI-1 content with platelets activation, as a result of streptokinase influence, can lead to new thrombotic complications risk.
Key words: hemostasis system, platelets, streptokinase, plasminogen activators inhibitor type I (PAI-1).
Published at the site: 2006-09-21
The original article in Ukrainian is available for download in PDF format.
© The Ukrainian Biochemical Journal