Journal archive > 2006 > N3, May-June

STREPTOKINASE INFLUENCE ON THE CONTENT OF PLASMINOGEN
ACTIVATOR INHIBITOR OF TYPE 1

N. K. Burlova-Vasyl’eva, Ie. M. Krasnobryzha, O. M. Savchuk, G. L. Volkov

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
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The influence of streptokinase on plasminogen activators inhibitor of type I (PAI-1) was investigated with the use of model systems in vitro and in vivo.
It was defined, that intravenous streptokinase injection causes an increase in PAI-1 content in mammals’ blood plasma. Experiments in vitro have shown that the increase in PAI-1 concentration takes place as a result of streptokinase action. It occurs due to platelets activation with subsequent PAI-1 secretion from their ?-granules. It is established, that PAI-1 is secreted by platelets both in free and in complex forms.
The data obtained in the work, allow to assume, that the simultaneous substantial increase in PAI-1 content with platelets activation, as a result of streptokinase influence, can lead to new thrombotic complications risk.

Key words: hemostasis system, platelets, streptokinase, plasminogen activators inhibitor type I (PAI-1).

Recieved: 2006-05-16

Published at the site: 2006-09-21

The original article in Ukrainian is available for download in PDF format.

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