Journal archive > 2006 > N3, May-June

INFLUENCE OF SOLUBLE FIBRIN ON THE BLOOD
COAGULATION PROCESS AND PLATELETS AGGREGATION

N. V. Zaichko1, T. M. Chernyshenko2, T. M. Platonova2, G. L. Volkov2

1Ukrainian State Scientific Research Institute of Invalid Rehabilitation, Vinnitsa;
2Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
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The accumulation of soluble fibrin (SF) in the blood plasma causes acceleration of the final stage of blood coagulation. It increases functional activity of a hemostasis system platelet link, that is the precondition of thrombotic complication. Accumulation of SF in the blood plasma is accompanied by proportional reduction of coagulation time in ancistron and thrombin time tests, and also the intensification of platelets aggregation process. A conclusion was drawn that for early diagnostics of the DIC-syndrom it is expedient to carry out complex estimation of the hemostasis system with obligatory definition of the blood SF content, performance of ancistron and thrombin time tests, and also study of platelets aggregation.

Key words: blood coagulation, soluble fibrin, platelet, DIC-syndrom.

Recieved: 2006-05-12
Published at the site: 2006-09-21

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal