Journal archive > 2006 > N3, May-June

CHARACTERIZATION OF PLATELETS AGGREGATION INHIBITOR FROM Agkistrodon blomhoffii ussuriensis SNAKE VENOM

V. L. Karbovskiy1,2, O. M. Savchuk2, G. L. Volkov2, N. V. Zaichko3, Ts. Buchan4

1Taras Shevchenko Kyiv National University, Ukraine;
2Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
3Ukrainian State Scientific Research Institute of Invalid Rehabilitation, Vinnitsa;
4Shidjir International Co., Mongolia, Ulan-Bator;
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Platelet aggregation inhibitor – “Blomus-B” from Agkistrodon blomhoffii ussuriensis venom has been isolated by affinity and ion-exchange chromatography. The purified inhibitor is a novel non-enzymatic single-chain protein with molecular weigth of 13 kDa. “Blomus-B” causes a change of platelets shape and takes effect on ADP- and adrenalin-induced platelet aggregation.

Key words: snake venom, platelets, platelet aggregation inhibitor, desintegrins.

Recieved: 2006-05-04
Published at the site: 2006-09-21

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal