CHARACTERIZATION OF PLATELETS AGGREGATION INHIBITOR FROM Agkistrodon blomhoffii ussuriensis SNAKE VENOM
1Taras Shevchenko Kyiv National University, Ukraine;
2Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
3Ukrainian State Scientific Research Institute of Invalid Rehabilitation, Vinnitsa;
4Shidjir International Co., Mongolia, Ulan-Bator;
Platelet aggregation inhibitor – “Blomus-B” from Agkistrodon blomhoffii ussuriensis venom has been isolated by affinity and ion-exchange chromatography. The purified inhibitor is a novel non-enzymatic single-chain protein with molecular weigth of 13 kDa. “Blomus-B” causes a change of platelets shape and takes effect on ADP- and adrenalin-induced platelet aggregation.
Key words: snake venom, platelets, platelet aggregation inhibitor, desintegrins.
Published at the site: 2006-09-21
The original article in Ukrainian is available for download in PDF format.
© The Ukrainian Biochemical Journal