EFFECTS OF CELL-BOUND PROTEIN A OF Staphylococcus aureus
ON?THE?LEVEL?OF INTRACELLULAR CALCIUM IONS AND ATPase
ACTIVITY OF ACTOMYOSIN IN SMOOTH MUSCLES
1Taras Shevchenko Kyiv National University, Ukraine;
2Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv;
Immune-active substance of Staphylococcus aureus, cell-bound protein A (CBPA), enhances the acetylcholine- or hyperpotassium (K+) Krebs solution-evoked excitation in Taenia coli smooth muscles. CBPA increases caffeine- and carbacholeevoked Ca2+ signals in smooth muscle cells suspension, loaded with indo-1, and also caffeine- and acetylcholine-evoked contraction in smooth muscles slices. Against a background of CBPA-suppressed action of sodium nitroprusside, ATP evokes the membrane depolarization. CBPA in small concentrations potentiates ATPase (Mg2+,Ca2+-; Mg2+- and Mg2+- in the presence of ЕGТА) activity of actomyosin in the smooth muscles.
Key words: smooth muscle cell, Staphylococcus aureus cell-bound protein A, ATPase activity, actomyosin, Ca2+ signal, electrical potential, smooth muscles.
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© The Ukrainian Biochemical Journal