Journal archive > 2006 > N 1 January-February

EFFECTS OF CELL-BOUND PROTEIN A OF Staphylococcus aureus
ON?THE?LEVEL?OF INTRACELLULAR CALCIUM IONS AND ATPase
ACTIVITY OF ACTOMYOSIN IN SMOOTH MUSCLES

N. V. Melenevska1, M. S. Miroshnichenko1, I. B. Philyppov2, O. Yu. Artemenko1, M.? F. ?Shuba2

1Taras Shevchenko Kyiv National University, Ukraine;
2Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv;
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Immune-active substance of Staphylococcus aureus, cell-bound protein A (CBPA), enhances the acetylcholine- or hyperpotassium (K+) Krebs solution-evoked excitation in Taenia coli smooth muscles. CBPA increases caffeine- and carbachole­­evoked Ca2+ signals in smooth muscle cells suspension, loaded with indo-1, and also caffeine- and acetylcholine-evoked contraction in smooth muscles slices. Against a background of CBPA-suppressed action of sodium nitroprusside, ATP evokes the membrane depolarization. CBPA in small concentrations potentiates ATPase (Mg2+,Ca2+-; Mg2+- and  Mg2+- in the presence of  ЕGТА) activity of actomyosin in the smooth muscles.

Key  words: smooth muscle cell, Staphylococcus aureus cell-bound protein A, ATPase activi­ty, actomyosin, Ca2+ signal, electrical potential, smooth muscles.

The original article in Ukrainian is available for download in PDF format.

 

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