Journal archive > 2005 > N 6, November-December

Molecularly imprinted polymers – tyrosinase mimics

S. A. Piletsky, I. A. Nicholls, M. I. Rozhko, T. A. Sergeyeva, E. V. Piletska, A. V. El’skaya, I. Karube

Synthetic polymers mimicking the enzyme tyrosinase have been prepared by the molecular imprinting of a complex between Cu (II) and catechol and ethyl ester of urocanic acid in an ethylene glycol dimethacrylate copolymer. Optimised polymer systems demonstrated catalysis, Michaelis-Menten kinetics and competitive inhibition similar to those of mushroom tyrosinase. The polymers benefited from superior chemical and mechanical stability in comparison with natural enzyme.

Recieved: 2005-07-05

Published at the site: 2006-12-26

The original article in English is available for download in PDF format.

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