Effect of eosin Y on ATPase activity of actomyosine complex of uterus smooth muscle (R.D. Labyntseva, S.O. Kosterin)

Journal archive > 2005 > N 5, September-October

Effect of eosin Y on ATPase activity of actomyosine complex of uterus smooth muscle

The effect of eosin Y (2,4,5,7 – tetrabromofluorescein; 0.1–100 ?M) on ATPase activity smooth muscle actomyosine was studied. The inhibition coefficient i₅₀ of ATPase activity with eosin Y was 0.74 ± 0.07 ?M. The inhibitor decreased V_max of actomyosine ATPase for ATP, but no influence on affinity of actomyosine for ATP was observed. It is suggested that eosin Y inhibits actomyosine ATPase activity noncompetitively in respect of ATP.

Recieved: 2005-02-24

Published at the site: 2005-10-10

The original article in Ukrainian is available for download in PDF format.