Journal archive > 2005 > N3, May-June

The molecular signaling mechanisms modulation in excitable cells by toxins andbacterial substances

N. V. Melenevska, M. S. MiroshnichenkoM. F. Shuba

The mechanisms of bacterial substances (protein A, peptidoglican Staphylococcus aureus), bacterium toxins (St. aureus, Corynebacterium diphtheriae, Shigella dysenteriae, Clostridium botulinum, Clostridium tetani, Vibrio choleral), transfer factor of immune reactivity to Staphylococcus aureus upon the key link (acetylcholine-, ATP-, inositol-1,4,5-triphosphate-, ryanodin-sensitive receptors, G-proteins, Са2+, К+-transporting systems, second messengers) in the chain of signal conduction of excitatory and inhibitory agonists in excitable cells were examined. The action of these immune-active substances upon contractile proteins ATP-ase activity and protein synthesis was also discussed.

Recieved: 2005-01-13

Published at the site: 2005-05-05

The original article in Ukrainian is available for download in PDF format.


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