Journal archive > 2005 > N2, March-April

Neuroprotective effect of N-acylethanolamines under chronic morphine dependence.
II. Effect on rat brain fatty acid composition

N. M. Gulaya, V. M. Margitich, V. M. Klimashevsky, T. M. Goridko, M. V. ArtamonovO. D. Zhukov

The effect of N-acylethanolamines mixture (NAE) with saturated and unsaturated acyl chains on the fatty acid composition of the rat brain under chronic morphine dependence was investigated. Long-term administration of NAE reduced morphine-induced decrease of mono- and polyunsaturated fatty acids in the rat brain crude lipid extract. Furthermore, NAE restored the acyl chain spectrum, especially the content of docosahexaenoic acid in essential phospholipids – phosphatidylcholine and phosphatidylethanolamine. Pharmacological activity of NAE depended on a dose.

Recieved: 2004-11-12

Published at the site: 2005-03-03

The original article in Ukrainian is available for download in PDF format.

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