Neuroprotective effect of N-acylethanolamines under chronic morphine dependence.
II. Effect on rat brain fatty acid composition
The effect of N-acylethanolamines mixture (NAE) with saturated and unsaturated acyl chains on the fatty acid composition of the rat brain under chronic morphine dependence was investigated. Long-term administration of NAE reduced morphine-induced decrease of mono- and polyunsaturated fatty acids in the rat brain crude lipid extract. Furthermore, NAE restored the acyl chain spectrum, especially the content of docosahexaenoic acid in essential phospholipids – phosphatidylcholine and phosphatidylethanolamine. Pharmacological activity of NAE depended on a dose.
Published at the site: 2005-03-03
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