Effect of ?-tocopherol and its derivatives on actinomycin D induced apoptosis of rat thymocytes
The induction of rat thymocyte apoptosis by actinomycin D was associated with the increased caspase-3 activity and DNA fragmentation, the both effects were attenuated by ?-tocopherol. Apoptosis was also decreased by ?-tocopheryl acetate, but these suppressive effects were less than those of ?-tocopherol.Tocopheryl quinone had no pronounced antiapoptotic effect. It was proposed that the difference in antiapoptotic effects of ?-tocopherol derivatives is attributed to structure properties of the chroman head group and to the ability for scavenging reactive oxygen species but it is not excluded that antiapoptotic activity of ?-tocopherol may exceed that of a mere antioxidant.
Published at the site: 2005-02-02
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