Journal archive > 2004 > #1 January-February

Expression of the lipopolysaccharide-receptors in the rat liver cells under normal and inflammatory conditions

N. V. BytesS. V. Hizhnyak

The liver can be a primary target organ for bacterial endotoxins – lipopolysaccharides, which serve as the major triggers of anaphylotoxin’s generation. Both lipopolysaccharides and anaphylotoxins induce the acute-phase reaction in the liver. The acute-phase reaction comprises a variety of systemic changes. Synthesis of several plasma proteins in the liver and glucose output from hepatocytes undergo dramatic changes during inflammation. These changes are mediated by soluble factors. Mechanism of signal transduction is reviewed in detail. Attention is payed to the differences between expression of the lipopolysaccharide receptors under normal and inflammatory conditions.

Recieved: 2003-06-05

Published at the site: 2004-02-02

The original article in Ukrainian is available for download in PDF format.