Journal archive > 2004 > N 6, November-December

The influence of iron ions on the antioxidant enzyme activities in yeast Saccharomyces cerevisiae

D. V. Gospodaryov, V. I. Lushchak

A complex of physiological and biochemical indices has been compared in wild and isogenic catalase-deficient strains of Saccharomyces cerevisiae grown on the media with different iron ion concentrations is 2 times higher in cytosolic catalase deficient yeast. Superoxide dismutase activity grown in the medium with 500 ?M of ferrous sulphate.

Under such conditions, peroxisomal catalase deficient yeast had a 2-fold decreased activity of superoxide dismutase. There is a significant difference between TBA-reactive substances content of the wild and cytosolic catalase deficient strain. It has been suggested that the repletion of iron ions in the growth medium leads to the formation of lipid oxidation products. Catalase prevents TBA-reactive substances formation in the given conditions and plays a protective role.

Recieved: 2004-03-12

Published at the site: 2004-12-12

The original article in Ukrainian is available for download in PDF format.