Journal archive > 2004 > N 6, November-December

Age peculiarities of cadmium cumulation in organs of intoxicated rats
and changes of indices of acid-alkaline state of blood under different
conditions of antioxidant protection

 Melnychuk, N. M. Melnikova, E. A. Derkach

Age peculiarities of cadmium cumulation in the organs of rats under different conditions of antioxidants administration. Considerable hepato- and nefrotoxic effect of the given xenobiotic under different conditions of its supply into the organism was revealed. The strongly pronounced differences between the age distribution of cadmium in the organisms have been marked. It is proved that the most antioxidantal activity is shown by sodium selenite when administered into the organism before poisoning with cadmium. It is stated that the indices showing the acid-alkaline state are subject to the greatest changes in the bodies of young animals. In this case they have more expressed toxic effects under the influence of ions of heavy metals as well as the receptivity to the positive influence of antioxidants.

Recieved: 2004-08-27

Published at the site: 2004-12-12

The original article in Ukrainian is available for download in PDF format.