Journal archive > 2004 > N3, May-June

Effect of a single emotional-algesic stress on the basic carboxypeptidases activity in rat brain regions and adrenals

A. N. Vernigora, Zh. S. Bardinova, V. A. Smetanin, M. T. Gengin

Effect of a single emotional-algesic stress on the carboxypeptidase H and PMSF-inhibited carboxypeptidase activities (phenylmethylsulphonilfluoride-inhibited carboxypeptidase) taking part in the final stage of formation of biologically active neuropeptides from precursors, was studied. Activity of the enzymes depended on duration of the stress and time after the stress in pituitary and adrenal glands. Differences in changes of carboxypeptidase H and PMSF-inhibited carboxypeptidase activities was found, especially in adrenals. The role of enzymes in emotional-algesic stress development and in metabolism of regulatory peptides by the stress was discussed.

Recieved: 2004-01-21

Published at the site: 2004-06-06

The original article in Russian is available for download in PDF format.