Journal archive > 2004 > N2, March-April

Changes in functional state of the low-molecular G proteins platelet under type 1 diabetes mellitus

N. O. Sybirna  O. I. VovkL. B. Drobot

Platelets from healthy donors and insuline dependent patients with type 1 diabetes mellitus were examined for proteins specifically interacting in vitro with GST-fused constitutively active (Val12) forms of small GTPases of Rac, Rho and Cdc42. Differential changes in pattern of proteins which bind to these G-proteins in diabetic platelets have been revealed. Obtained results suggest that signalling pathways mediated by Rho GTPases are altered under type 1 diabetes mellitus. Such changes of actin cytoskeleton regulation may contribute to the higher level of platelet aggregation, which prove to be the etiological background of the late diabetes complications.

Recieved: 2003-11-10

Published at the site: 2004-04-04

The original article in Ukrainian is available for download in PDF format.